Prescription · ppis
Proton Pump Inhibitors (PPIs)
Omeprazole · Esomeprazole · Pantoprazole · Lansoprazole
Mechanism
Block gastric acid production by inhibiting the hydrogen-potassium ATPase in parietal cells.
Environmental footprint
Alters stomach acid environment. Changes gut microbiome composition. May affect nutrient absorption over years.
What the evidence shows
Effective for GERD and peptic ulcer disease. Long-term use associated with B12, magnesium, and calcium absorption issues, gut microbiome shifts, and debated bone density effects.
Systems affected
Biome maps medication footprints; it does not recommend starting, stopping, or changing any prescription. Always consult your prescriber or pharmacist.